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基质金属蛋白酶及其抑制剂与肿瘤关系的研究进展 被引量：7

Advances of martix metalloproteinase and tissue inhibitors of metalloproteinase families in tumors
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摘要 基质金属蛋白酶是一组蛋白水解酶 ,能降解细胞外基质 ,金属蛋白酶组织抑制剂则能抑制其水解活性 ,这两组酶在很多肿瘤组织中表达增高。综述了金属蛋白酶及其抑制剂表达的失衡与肿瘤侵袭及转移的关系。
作者 张金库
机构地区 保定市第一中心医院病理科
出处 《诊断病理学杂志》 CSCD 2004年第4期269-271,共3页 Chinese Journal of Diagnostic Pathology
关键词 肿瘤 基质金属蛋白酶 金属蛋白酶组织抑制剂 表达 水解活性 研究进展 细胞外基质 组蛋白 水解酶
分类号 R730.54 [医药卫生—肿瘤] R737 [医药卫生—肿瘤]
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参考文献22

  • 1袁发焕,王海燕,李惊子.ECM,MMPs/TIMPs及其调节研究进展[J].国外医学（生理病理科学与临床分册）,2000,20(2):93-96. 被引量：44
  • 2Sato H, Takino T, Okada Y, et al. A matrix metallproteinase expressed on the surface of invasive tumor cells[J]. Nature, 1994,370(6484):61-65.
  • 3张志刚.基质金属蛋白酶及其抑制剂与疾病的关系[J].国外医学（生理病理科学与临床分册）,1997,17(4):351-353. 被引量：14
  • 4Kadono Y, Okada Y, Namiki M. Transformation of epithelial MadinDarby canine kidney cells with p60-src induced expression of mambrinetype 1 matrix metalloproteinase and invasiveness [ J ]. Cancer Res,1998,58 (10): 2240 - 2244.
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  • 8Anand Apte B, Bao L, Smith R, et al. A review of tissue inhibitor of metalloproteinases-3(TIMP-3) and experimental analysis of its effect on primary tumor growth [J]. Biochem Cell Biol, 1996,74 (6): 853-862.
  • 9Yoshiji H, Harris SR, Raso E, et al. Mammary carcinoma cells overexpressing tissue inhibitor of metalloproteinases-1 show enhanced vascular endothelial growth factor expression [J]. Int J Cancer, 1998,75(1):81-87.
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二级参考文献6

  • 1Thomas Krieg,E. Carwile LeRoy. Diseases of the extracellular matrix[J] 1998,Journal of Molecular Medicine(3-4):224～225
  • 2Leena Bruckner-Tuderman,P. Bruckner. Genetic diseases of the extracellular matrix: more than just connective tissue disorders[J] 1998,Journal of Molecular Medicine(3-4):226～237
  • 3M. Aumailley,B. Gayraud. Structure and biological activity of the extracellular matrix[J] 1998,Journal of Molecular Medicine(3-4):253～265
  • 4K. Gohji,M. Nomi,I. Hara,S. Arakawa,S. Kamidono. Influence of cytokines and growth factors on matrix metalloproteinase-2 production and invasion of human renal cancer[J] 1998,Urological Research(1):33～37
  • 5B. Huppertz,Sonja Kertschanska,Ayse Yasemin Demir,Hans-Georg Frank,Peter Kaufmann. Immunohistochemistry of matrix metalloproteinases (MMP), their substrates, and their inhibitors (TIMP) during trophoblast invasion in the human placenta[J] 1997,Cell & Tissue Research(1):133～148
  • 6L.J. Denis,J. Verweij. Matrix metalloproteinase inhibitors: Present achievements and future prospects[J] 1997,Investigational New Drugs(3):175～185

共引文献54

同被引文献80

引证文献7

二级引证文献19

诊断病理学杂志
2004年 第4期

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