乳腺原发性血管肉瘤2例报道并文献复习

Primary angiosarcoma of breast: a report of two cases and review of literature

目的 探讨乳腺血管肉瘤的临床病理特点、治疗和预后。方法 对 2例原发于乳腺的血管肉瘤进行组织形态学和免疫组化分析 ,并复习文献。结果 乳腺血管肉瘤几乎均发生于女性 ,主要为绝经期前女性。临床表现不典型 ,组织学变化大 ,肿瘤通常CD31、CD34、UEA 1和F8(+) ,B72 3对上皮样血管肉瘤具有特异性。目前主要采取手术治疗 ,一般不主张腋窝清扫 ,术后放、化疗效果不肯定。结论 乳腺原发性血管肉瘤较少见 。

Objective To study the clinical pathological characteristics, therapeutic procedure and prognosis of angiosarcoma in breast. Methods Two cases of primary angiosarcoma of breast were reported with review of the literature. Histological appearances and immunohistochemistry were analyzed. Results Primary angiosarcoma of breast usually affected premenopausal women.Clinical manifestation was not typical and the histological features varied greatly. The tumor cells expressed CD31, CD34, UEA-1 and F8. B72.3 positive reactivity was helpful in diagnosis of epithelioid angiosarcomas. At present total mastectomy was the recommended primary surgical therapy and general axillary dissection was not indicated. After excision the role of chemotherapy and radiotherapy was not determined. Conclusion Primary angiosarcoma of breast is a rare neoplasm. The histological grading of the tumors correlates closely with the prognosis.