L－和DL－正丁基东莨菪碱对大鼠子宫作用的比较

COMPARISONOFPHARMACOLOGICALEFFECTSOFL- ANDL-N-BUTYL-SCOPOLAMINEINRATUTERUS

用放射配基结合法测定Ｌ－正丁基东莨菪碱，ＤＬ－正丁基东莨菪碱与阿托品对大鼠子宫Ｍ胆碱受体的亲和力。结果表明，Ｌ－与ＤＬ－正丁基东莨菪碱对大鼠子宫Ｍ胆碱受体的亲和力十分相近，但都比阿托品弱。比较Ｌ－正丁基东莨菪碱、ＤＬ－正丁基东莨菪碱和阿托品对离体大鼠子宫的影响及对抗乙酰胆碱所致的子宫收缩作用，表明两种正丁基东莨菪碱对离体大鼠子宫无影响，而能对抗乙酰胆碱所致的子宫收缩，旦作用相近，但都比阿托品弱。说明生物效应与其受体亲和力的大小相关。

heaffinitiesof L-n-butyl-scopolamine,DL-n-butyl-scopolamine andatropine for the M-cholinergic receptors of rat uterus were compared using radioligand binding assay.Resultsshowed that the affinity of L- n- butyl-scopolamine for the M-receptors was similar to that of Dl- n-butyl-Scoplamine,but lower than that of atropine. In isolated rat uterus,L-and DL- n- butyl-scopolamine were found not to in fluence the automatic contraction but antagonize the contractioninduced by acetylcholine with nearly the same PA2,although the PA2 of both compounds were stilllower than that of atropine. Therefore ,no difference between L -and DL- n- butyl- scopolamine ineither biological activity or receptor affinity was observed.