摘要
从炮制前后的马钱子中，提取分离和鉴定了１６个生物碱，其中异马钱子碱、异马钱子碱氮氧化物、异番木鳖碱、氮氧化物、２－羟基，３－甲氧基番木鳖碱为新生物碱。经光谱（１３ＣＮＭＲ，１ＨＮＭＲ，ＩＲ，ＵＶ和ＭＳ）解析，确定其结构。通过实验发现，用１３ＣＮＭＲ谱测定马钱子中生物碱的结构，具有简便、快速等优点，且各化合物及其衍生物的共振峰呈现一定的规律。
In the course of our studies on the drug-processing of the seeds of
Strychnos nux- vomical,sixteen alkaloids were isolated and
identified from the heat treated and untreated seeds of S.
nux-vomica. Isobrucine ,isobrucine-N-oxide ,isostrychnine-N- oxide
and 2- hydroxy-3-methoxystrychnine were new alkaloids. The
1HNMR,13CNMR,MS ,IR and UV spectra were performed forall of the com
pounds.Applicaltion of 13CNMR to structure deter mination of
strychnos alkaloidsshowed high sensitivity, selectivity and time
efficiency.The 13CNMR spectra of these compoundsshowed some
regularities.
出处
《药学学报》
CAS
CSCD
北大核心
1994年第1期44-48,共5页
Acta Pharmaceutica Sinica
关键词
生物碱
马钱子
炮制
NMR
CNMR spectra
Strychnos alkaloids
Processing
of Strychnos nux-vomica L.
