摘要
丹皮酚抗大鼠心肌缺血再灌注损伤与抗膜脂质过氧化作用张卫国，张志善（武汉湖北医科大学药理教研室４３００７１）丹皮酚是非甾体类解热镇痛药，有抗动脉粥样硬化斑块形成、抑制血小板聚集（１），及抗心律失常和降压作用（２），并对钙反常培养乳鼠心肌细胞Ｃａ２＋内流...
Paeonl60
mg·kg-1ip,was given to rats for 15 days.On the 16th day myocar-dial
ischemia reperfusion injury was produced in the rat heart by
occlusion of the left coronary arteryand the release of the
occlusion. The results showed that paeonol signi ficantly improved
myocardialSOD activity(5.8±0.6.mg-1 compared with reperfusion
control 3.4±0.9,P<0. 01),reducedthe MDA content(11.4±1.7 nmol·
mg-versus17±1.3,P<0. 01 ) and cardiac CPK release(1523±
478.5U·L-versus2355±626.5,P <0.01).The myocardial ultrastructure
was alsoprotected keeping them from the oxygen free radical damage.It
appears that paeonol is an efficientprotective agent against ischemia
reperfusion damage in the rat heart.
出处
《药学学报》
CAS
CSCD
北大核心
1994年第2期145-148,共4页
Acta Pharmaceutica Sinica
关键词
丹皮酚
心肌缺血
再灌注损伤
Paeonol
Myocardial
protective effect
Antilipid peroxidation
Myocardial ultrastruc-ture
