摘要
关附甲素抑制犬冠脉结扎引起的心律失常王友群，苏玲，龚国清，刘静涵（南京中国药科大学药理研究室，中草药化学教研室２１０００９）关附甲素（ｇｕａｎｆｕｂａｓｅＡ，ＧＦＡ）是从关白附子中提取的一种二萜类生物碱（１，２）。现已发现它能抑制乌头碱、哇巴因和氯化...
Harris tow- stage left anterior coronary ligation was performed in
anesthetizeddogs.After twenty hours,severe ventricular arrhythmias
were recorded under conscious state.Cumu-lative intravenous
injections of guanfu base A,a new alkaloid isolated from the tuber of
Aconitumcoreanum in China,from 1 0 to 4 0 mg· kg-1produced
remarkable antiarrhythmic effect lasting over30 min and a moderate
reduction of heart rate. The P-R interval,QRS complex and Q-Tinterval
ofthe sinus rhythm were not significantly altered.The antiarrhythmic
potency of guanfu base A in thismodel was found to be about one third
that of quinidine.
出处
《药学学报》
CAS
CSCD
北大核心
1994年第2期141-144,共4页
Acta Pharmaceutica Sinica
关键词
关附甲素
心律失常
白附子
附子
Guanfu base A
Myocardial
infarction
Ventricular arrhythmias
Antiarrhythmic agents
