兴安升麻酚性甙成分的研究

STUDIES ON PHENOLIC GLYCOSIDES ISOLATED FRoM CIMICIFUGA DAHURICA

从中药兴安升麻［Ｃｉｍｉｃｉｆｕｇａｄａｈｕｒｉｃａ（Ｔｕｒｃｚ．）Ｍａｘｉｍ．］的根茎中分得三个新结构的酚甙类，即异升麻酰胺（ｉｓｏｃｉｍｉｃｉｆｕｇａｍｉｄｅ，Ｉ）、北升麻瑞（ｃｉｍｉｄａｈｕｒｉｎｅ，ＩＩ）和北升麻宁（ｃｉｍｉｄａｈｕｒｉｎｉｎｅ，ＩＩＩ），其中Ｉ为升麻酰胺（ｃｉｍｉｃｉｆｕｇａｍｉｄｅ，ＩＶ）的几何异构体，而ＩＩ和ＩＩＩ则分别为３，４－二羟基－β－苯乙醇－３－Ｏ－β－Ｄ－吡哺半乳糖甙和３，４－二羟基－β－苯乙醇－３－Ｏ－β－Ｄ－吡喃葡萄糖甙。由光谱数据（ＩＲ，ＭＳ，１Ｈ和１３Ｃ－ＮＭＲ及ＮＯＥ差谱）阐明了它们的化学结构。另外还分得蔗糖（Ｖ）。

Three new amorphous phenolic glycosides ,isocimicifugamideI), cimidahurine(II)and cimidahurinine(III),have been isolated from the rhizomes of Cimicifuga dahurica.Theirchemical structures were established on the hasis of spectral data(IR,MS,1H and 13CNMR,NOEdifference spectra):I,C25H31NO10,[a]D一46.2 °,N-(3'-methoxy-4'- hydroxyphenethy1)-4-O-β -D-galactopyranosyl-isoferulamide, a geometric isomer of cimicifugamide(IV).II.C14H20O8,[a]D一51.4°,3,4-dihydroxyl-β -phenethanol-3-O-β-D-galactopyranoside.III,C14H20O8,[a]D-45.6 °,3,4-dihydroxyl-β-phenethanol-3-O-β-D-glucopyranoside.The isolation also afforded sucrose(V).