摘要
对３类１４种吡唑烷酮类化合物的抗惊厥作用进行了比较研究，它们对最大电休克惊厥均有对抗作用，作用出现快，但维持时间较短，其中ＩＩ－ｆ作用最强，对听源性发作和家兔海马注射硫酸锌形成的慢性癫痫模型也有效。此外，ＩＩＩ－类尚能对抗戊四唑引起的阵挛性惊厥。
The
anticonvulsive activity of three kinds of pyrazolidinones:5-benzyl-
substitut-ed-3-pyrazolidinones;5-benzyl-1-alkyl substituted and
1-alkyl substituted-3-pyrazolidinones werestudied. Fourteen
substitutes of these three kinds of pyrazolidinones were found to be
potent anticonvul-sants.In doses less than TD50,they were found tO be
able to protect mice and rats from seizuresproduced by maximal
electroshock seizure(MES),such action appeared rapidly and lasted for
a shortperiod。II-f was shown to be the most potent anti-MES agent
among these three kinds of pyrazolidi-nones.It also showed
therapeutic effect in treating experimental epilepsy produced by
intrahippocam-pal injection of zinc sulfate in rabbits and audiogenic
seizures in rats.The third kind of pyrazolidinonesa1so showed
anti-metrazol induced seizures in mice.
出处
《药学学报》
CAS
CSCD
北大核心
1994年第3期166-170,共5页
Acta Pharmaceutica Sinica
基金
国家医药管理局和中国自然科学基金
