摘要
一般认为水杨酸类药物仅降低处于高热状态的体温而不影响正常体温。但本文实验表明,大剂量阿斯匹林(ASP)(200mg·kg-1,ip)使雄性ICR小鼠的正常体温明显下降,且该作用呈昼夜节律性变化。ASP用药后血浆水杨酸浓度也呈昼夜变化,但与药物的体温降低作用无明显的正相关关系。提示ASP用药后的体温降低作用的昼夜节律主要与动物体温的昼夜节律相关。
It is generillly believed that the effectivenes of
salicylates , such as aspirin(ASP) ,is restricted to the lowering of
the body temperature(BT ) previously elevated by pyrogensand that
salicylates have no effect on normal BT,We present here evidences
which demonstrate thatASP does lower the normaI BT of mice kept in a
24℃ environment.Male ICR mice, housed under alight-dark cycle(LD 12
:12h)at a room temperature of 24±1℃ and a humidity of 60±
10%withfood and water ad libitum,received intraperitoneal injections
of ASP 25,100 and 200 mg· kg-1.Theanimals showed a significant
decline in their rectal temperature and the BT returned to the values
thatprevailed before drug administration within 4 h.There was an
orderly, progressive dose- dependentdecrease in BT,A significant
circadian rhythm was demonstrated for ASP-induced hypothermal
effectin mice. Although a significant circadian、rhythm was also
demonstrated for the plasma salicylateconcen trations at l h after
dosing ,there seems to be no positive relationship between plasma
drugconcentrations and the drug response;The results suggest that ASP
does affect normal BT regulation inmice and that the circadian rhythm
change in ASP-induced hypothermal effect may be mainly due tothe
rhythms,in the sensitivity of mice to the drug.
出处
《药学学报》
CAS
CSCD
北大核心
1994年第5期330-334,共5页
Acta Pharmaceutica Sinica