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阿斯匹林对小鼠正常体温的降低作用及其昼夜节律变化

THE NORMAL BODY TEMPEKATUKE LOWERING EFFECT OF ASPIRIN IN MICE ANDITS CIADIAN RHYTHM
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摘要 一般认为水杨酸类药物仅降低处于高热状态的体温而不影响正常体温。但本文实验表明,大剂量阿斯匹林(ASP)(200mg·kg-1,ip)使雄性ICR小鼠的正常体温明显下降,且该作用呈昼夜节律性变化。ASP用药后血浆水杨酸浓度也呈昼夜变化,但与药物的体温降低作用无明显的正相关关系。提示ASP用药后的体温降低作用的昼夜节律主要与动物体温的昼夜节律相关。 It is generillly believed that the effectivenes of salicylates , such as aspirin(ASP) ,is restricted to the lowering of the body temperature(BT ) previously elevated by pyrogensand that salicylates have no effect on normal BT,We present here evidences which demonstrate thatASP does lower the normaI BT of mice kept in a 24℃ environment.Male ICR mice, housed under alight-dark cycle(LD 12 :12h)at a room temperature of 24±1℃ and a humidity of 60± 10%withfood and water ad libitum,received intraperitoneal injections of ASP 25,100 and 200 mg· kg-1.Theanimals showed a significant decline in their rectal temperature and the BT returned to the values thatprevailed before drug administration within 4 h.There was an orderly, progressive dose- dependentdecrease in BT,A significant circadian rhythm was demonstrated for ASP-induced hypothermal effectin mice. Although a significant circadian、rhythm was also demonstrated for the plasma salicylateconcen trations at l h after dosing ,there seems to be no positive relationship between plasma drugconcentrations and the drug response;The results suggest that ASP does affect normal BT regulation inmice and that the circadian rhythm change in ASP-induced hypothermal effect may be mainly due tothe rhythms,in the sensitivity of mice to the drug.
出处 《药学学报》 CAS CSCD 北大核心 1994年第5期330-334,共5页 Acta Pharmaceutica Sinica
关键词 阿斯匹林 体温降低作用 昼夜节律 Aspirin Hypothermal effect Circadian rhythm
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