剖宫产术后硬膜外镇痛对C-反应蛋白水平的影响

Effect of postoperative epidural analgesia after cesarean section on whole blood C-reactive protein

目的 观察剖宫产术后硬膜外镇痛对C-反应蛋白(CRP)水平的影响。方法 选择36例健康足月产妇,择期在连续硬膜外麻醉下行剖宫产术。术毕随机分为三组:A组,对照组(n=12):不使用镇痛;B组,吗啡镇痛组(EPI组,n=12);C组,硬膜外自控镇痛组(PCEA组,n=12)。术后随访72h,采用免疫散射比浊法测定全血CRP水平。结果 B组术后第24h和C组术后第24、72h的CRP水平均低于对照组,差异具有显著性意义(P<0.05)。结论 剖宫产术后有效的硬膜外镇痛可影响并使血CRP水平降低,有利于机体的免疫自稳。

Objective To observe the effect of postoperative epidural analgesia after cesarean section on whole blood level of C - reactive protein. The aim is to compare stress response related to different analgesic techniques. Methods Thirty - six full - term parturients undergoing elective cesarean section under epidural anesthesia were randomly divided into three groups: the control group(group A,n= 12) ,the analgesia with epidural morphine group(group B,n = 12)and the patient - controlled epidural analgesia group(group C,n = 12) Postoperative fol-low - up was 72 h. The whole blood C - reactive protein was determined with the scattering immunoturbidimetry. Results The whole blood level of C - reactive protein at postoperative 24 h of group B and 24, 72 h of group C were significantly lower than the group A(P < 0.05) . Conclusion The postoperative epidural analgesia after cesarean section can significantly decrease the blood level of C - reactive protein.