摘要
采用ＧＣ－ＭＳ联用技术，对尿中的沙丁胺醇（ｓａｌｂｕｔａｍｏｌ）进行分析。实验表明，口服一片沙丁胺醇（２．４ｍｇ），可于２４ｈ从尿中排泄，且以游离形式为主。样品提取时，控制溶液ｐＨ为８．８时，提取率较高。本方法对沙丁胺醇定性简单、快速、准确.
Salbutamol(2.4mg) was administrated to a healthy male.
The urine wasanalysed by GC-MS.95%of the drug was excreted in 24 h in
unconjugated form.The pH of urinewas shown to strongly affect the
extraction rate,good recovery was obtained at pH 8.8.With
thismethod,salbutamol can be determined simply,quickly and accurately.
出处
《药学学报》
CAS
CSCD
北大核心
1994年第6期454-458,共5页
Acta Pharmaceutica Sinica
