金华地区结核分枝杆菌耐药谱变化分析

A Investigation on Changing Tendency of Drug-resistant Spectrum of Mycobacterium Tuberculosis in Jinhua Area

[目的]探讨金华地区1980—1986年(A年段)和1999—2003年(B年段)结核菌耐药谱的变化。[方法]对两个 年段1300例住院病人按《全国结核病细菌学检验规程》的要求,用改良罗氏法进行痰结核菌培养、菌种鉴定和药物敏感 性试验。[结果]两个年段结核菌耐药谱变化的特征:结核菌总耐药率下降,耐利福平跃居首位,耐多药率和中老年肺结 核耐药率均呈上升趋势,其中以耐多药率升高为甚。[结论]我市B年段结核菌总耐药率比A年段呈下降态势,但与全国 比较还处于较高水平,尤其值得警示的是耐多药现象相当严重。

To investigate the changing tendency of drug resistant spectrum of Mycobacterium tuberculosis (MT) for inpatients with pulmonary tuberculosis in 1980-1986 and 1999-2003 The MT culture and identification and drug susceptibility test for 1 300 inpatients were performed by reformed L J medium according to national testing methods of tuberculosis bacterilolgy The changing tendency of drug resistant spectrum of MT was as follows: The total drug resistant rate was decreased for two periods First one is resistant to rifampin (RFP) The multidrug resistant rate was increasing especially as well as drug resistant rate in adults and aged cases Comparing to 1980-1986, the total drug resistant rate was decreased in 1999-2003 But the rate was still in high lever in China The multidrug resistance should be paid more attention in the future