摘要
合成的促性腺激素释放多肽(GRP)及其类似物GRp~NH2,[Glu7.9.14Lys6.10]GRP(6~14),[phe14]GRP(5~14)和[phe14]GRP浓度在0.05mmol·L-1时,具有刺激体外培养的小鼠垂体分泌LH的作用。其活性依此相当对照垂体的115.4,114.2,140,160和179%。小鼠于妊振第7~9天或第1~5天,每只sc[phe14]GRP1mg·d-1,或于妊娠第2~4天每只sc[phe14]GRP(5~14)1mg·d-1,有40~60%的妊娠动物出现死胎。
Synthetic GRP and its
analogues ,GRP-NH2,[Glu7.9.14 Lys6.10] GRP(6~14),[Phe14]GRP(5~
14)and[Phe14]GRP,at the concentration of 0.05 mmol·L-1 were shown
tohave stimulatory effect on LH secretion in cultured mouse pituitary
in vitro. The luteotropin releasingactivity of GRP and its analogues
was estimated to be 115.4,114.2,140.0,162.0 and 179.0%ofthe control
group,respectively. Subcutaneous administration of [Phe14]GRP on days
7~9 and 1~5 of pregnancy and [phe14]GRP(5~14)on days 2~4 of
gestation at dosage of 1 mg·d-1(eachmouse)caused fetal death in 40~
60% of mice.
出处
《药学学报》
CAS
CSCD
北大核心
1994年第8期581-584,共4页
Acta Pharmaceutica Sinica
关键词
促性腺激素
释放多肽
促黄体素
Gonadotropin-releasing peptide
Interruption of
early pregnancy
Anti-implanta-tion
LH