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促性腺激素释放多肽(GRP)对体外培养小鼠垂体分泌LH的影响

EFFECT OF GONADOTROPIN-RELEASING PEPTIDE(GRP)ON LH SECRETION OF MOUSE PITUITARY IN VITRO
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摘要 合成的促性腺激素释放多肽(GRP)及其类似物GRp~NH2,[Glu7.9.14Lys6.10]GRP(6~14),[phe14]GRP(5~14)和[phe14]GRP浓度在0.05mmol·L-1时,具有刺激体外培养的小鼠垂体分泌LH的作用。其活性依此相当对照垂体的115.4,114.2,140,160和179%。小鼠于妊振第7~9天或第1~5天,每只sc[phe14]GRP1mg·d-1,或于妊娠第2~4天每只sc[phe14]GRP(5~14)1mg·d-1,有40~60%的妊娠动物出现死胎。 Synthetic GRP and its analogues ,GRP-NH2,[Glu7.9.14 Lys6.10] GRP(6~14),[Phe14]GRP(5~ 14)and[Phe14]GRP,at the concentration of 0.05 mmol·L-1 were shown tohave stimulatory effect on LH secretion in cultured mouse pituitary in vitro. The luteotropin releasingactivity of GRP and its analogues was estimated to be 115.4,114.2,140.0,162.0 and 179.0%ofthe control group,respectively. Subcutaneous administration of [Phe14]GRP on days 7~9 and 1~5 of pregnancy and [phe14]GRP(5~14)on days 2~4 of gestation at dosage of 1 mg·d-1(eachmouse)caused fetal death in 40~ 60% of mice.
机构地区 中国医学科学院
出处 《药学学报》 CAS CSCD 北大核心 1994年第8期581-584,共4页 Acta Pharmaceutica Sinica
关键词 促性腺激素 释放多肽 促黄体素 Gonadotropin-releasing peptide Interruption of early pregnancy Anti-implanta-tion LH
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  • 1Li C H,Proc Natl Acad Sci USA,1987年,84卷,959页
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