摘要
用随机交叉设计，研究了藏、汉族健康人安替比林和醋氨酚的代谢差异。１６例汉族人安替比林Ｔ１／２为１８．８±４．８９ｈ，１７例藏族人为１５．０±３．０２ｈ（Ｐ＜０．０５），汉族人安替比林清除率是１．３５±０．３７Ｌ·ｈ－１，藏族人是１．７１±０．４４Ｌｔ·ｈ－１（Ｐ＜０．０５）。汉族人醋氨酚Ｔ１／２是３．１±０．８６ｈ，藏族人是３．２±１．１２ｈ（Ｐ＞０．０５）。实验结果表明，藏、汉族健康人安替比林的代谢有显著差异，藏族人安替比林清除率比汉族人增加了２０％。藏、汉族醋氨酚的代谢无明显差异。
The differences in disposition of
antipyrine and acetaminophen between Tibetan and Han healthy
volunteers were studied in a randomized crossover design. The
half-life of antipyrine was found to be 18.8±4.89 h in 16 Han and
15.0±3.02 h in 17 Tibetan(P<0.05) and the clearance was 1.35±0.37
L·h-1 in Han and 1.71±0.44 L·h-1 in Tibetan(P<0.05). The half-life
of acetaminophen was 3.1±0.86 h in Han and 3.2±1.12 h in
Tibetan(P>0.05).The experimental results indicate that the
disposition of antipyrine between Tibetan and Han healthy volunteers
significantly differed,the clearance of antipyrine in Tibetan
increased by 20%,but the disposition of acetaminophen between the two
ethnic groups showed no difference.
出处
《药学学报》
CAS
CSCD
北大核心
1994年第8期566-569,共4页
Acta Pharmaceutica Sinica
关键词
安替比林
醋氨酚
药代动力学
Antipyrine
Acetaminophen
Pharmacokinetic
Tibetan and Han
nationalities
