旋光活性内酯化合物的研究：（—）MALYNGOLIDE的全合成

STUDIES ON OPTICALLY ACTIVE LACTONE COMPOUNDS:TOTAL SYNTHESIS OF( )-MALYNGOLIDE

以己二酸为起始原料，成功地合成了有手性季碳中心的内酯化合物（—）－Ｍｉａｌｙｎｇｏｌｉｄｅ（１），其中关键的步骤采用手性相转移催化剂进行立体选择烷基化反应，此合成路线短，总收率为１０．５％。

The title compound had been synthesized from adipic acid(starting material) ineight stepe,in 10.5% over all yield.A chiral phase transfer catalyst was used to promote the stereose-lectivity alkylation reactions in the key steps of forming chiral centers.