摘要
雷公藤单─有效成分Ｔ＿４对类风湿关节炎患者滑膜细胞产生前列腺素Ｅ＿２的影响要庆平，张乃峥（北京协和医院北京１００７３０）雷公藤（ＴｒｉｐｔｅｒｙｇｉｕｍｗｉｌｆｏｒｄｉｉＨｏｏｋ）的半纯品多甙（Ｔ２）目前较多地用于类风湿关节炎（ＲＡ）。近年来从Ｔ２中...
The effects of
tripchlorolide ,an active ingredient(T4)of Tripterygium uilfordii
Hook on the production of prostaglandin E2(PGE2)by synovial cells of
rheumatoid arthritis(RA)patients were investigated.Six cases of
definite RA(female 5,male 1,mean age 45 with an average course of
disease of 9 years )were selected.Surgically obtained synovium
specimen were dissociated into digested synovial single cells(DSSC).
The cells were incubated with various concentrations of T4 for 48
hours.Using radioimmunoassay T4 was found to significantly inhibit
the production of PGE2(control 6.10±2.30vs T4 treated 0.58±0.17×
10-5mol·L-1) by short-term cultured DSSC of RA patients. The result
of this study suggests that T4 may be useful in the forthcoming
treatment of RA due to its inhibition of production of PGE2 by
synovial cells.
出处
《药学学报》
CAS
CSCD
北大核心
1994年第10期790-792,共3页
Acta Pharmaceutica Sinica
