绝经早期妇女龈沟液白细胞介素-6与牙周炎的关系

The association between Interleukin-6 in gingival crevicular fluid(GCF) and periodontitis in early menopausal women

目的:探讨白细胞介素- 6(IL- 6)与绝经早期妇女牙周炎的关系。方法:选择30例非牙周炎和49例患慢性中、重度牙周炎的维吾尔族(维族)妇女,所有妇女绝经年限均≤5年。采集30颗牙周健康牙和49颗牙周炎患牙的龈沟液(GCF)样本,随后记录牙周临床观察指标。应用放射免疫分析法检测GCF中IL- 6的含量。结果:牙周健康组GCF中IL -6的含量为(1 088.10±102.33) pg/ml,慢性牙周炎组GCF中IL 6 的含量为(2 961.22±224.80)pg/ml, 慢性牙周炎组明显高于牙周健康组(P<0.005);经相关分析,慢性牙周炎患牙GCF中IL -6 的含量与GI、PPD、CAL均呈正相关( r=0.564,P<0.005;r=0.335,P<0.05;r=0.324,P<0.05)。结论:绝经早期的妇女健康牙GCF中含有少量IL 6。GCF中IL- 6的产生增加可能与牙周炎的发生、发展有关,同时IL- 6 的水平反映了牙周炎症的严重程度,可以尝试作为判断牙周病变程度的一个指标。

Objective:To analyze the association between GCF IL-6 level and common clinical measurements of periodontitis in early menopausal women. Methods:Forty-nine moderate/severe chronic periodontitis patients and 30 non-periodontitis subjects, all Uyghur women within 5 years after menopause were enrolled in the study. 30 GCF samples were harvested from healthy sites of 30 non-periodontitis subjects, 49 GCF samples from chronic periodontitis sites of 49 chronic periodontitis subjects. Clinical measurements of each tooth were recorded after obtaining GCF samples. GCF IL-6 was measured by 125I radioimmunoassay (RIA). Results:The mean concentration of GCF IL-6 from healthy sites was (1088.10±102.33) pg/ml. The mean concentration of IL-6 from chronic periodontitis sites was (2961.22±224.80) pg/ml, significantly higher than that of healthy sites (P<0.005). Positive correlation was found between GCF IL-6 level and clinical measurements (GI, PPD and CAL) (r=0.564, P<0.005; r=0.335, P<0.05; r= 0.324, P<0.05). Conclusions:These findings suggest that there are lower IL-6 in GCF from healthy sites of early menopausal women; the increasing production of IL-6 may be associated with the initiation and progress of perodontitis. IL-6 may be a valuable indicator of the severity of periodontitis.