妊娠期高血压患者血中内皮素和一氧化氮水平及其临床意义

Levels of Endothelin and Nitric Oxide and Clinical Sense in Patients with Hypertensive Disorder Complicating Pregnancy

目的探讨内皮素和一氧化氮在妊娠期高血压发病中的作用。方法检测60例妊娠期高血压患者和58例正常晚期孕妇血中内皮素和一氧化氮的水平。结果(1)妊娠期高血压患者组血浆内皮素(ET)水平明显高于正常晚期妊娠组(P<0.01);(2)血浆ET水平越高,妊娠期高血压病情越重;(3)妊娠期高血压组血清一氧化氮(NO)水平明显低于正常晚期妊娠组(P<0.01);(4)血清NO水平与妊娠期高血压严重程度无明显相关性。结论血浆ET水平升高、血清NO水平下降与妊娠期高血压疾病发病有关。

OBJECTIVE To investigate Endothelin(ET)and Nitric Oxide(NO)role in the pathogenes is of hypertensive disorder complicating pregnancy(HDCP). METHODS ET and NO levels of 60 hypertensive disorder complicating pregancy patraents and 58 normal term pregant women were determined. RESULTS(1) ET level was significantly higher in hypertensive disorder complicating pregnancy group than that of control groups(P<0.01).(2)The higher is ET level,the severe is HDCP.(3)NO level was significantly lower in HDCP group than that of control group(P<0.01).(4)There was no any associating between NO level and severety of HDCP.CONCLUSION The increased of ET level and decreased of NO level may be one of the reasons of HDCP.