中药CA的急性毒性和长期毒性研究

Acute toxicity and long-term toxicity of Chinese medicine CA

采用最大耐受量测定法和30d喂养试验,测定小白鼠的最大耐受量和长期毒性.急性毒性试验结果表明,小白鼠灌胃最大耐受量为160g/kg(生药),相当于日临床用药量的160倍;30d长期毒性试验结果表明,小白鼠的一般状况、体重、血液学指标、血液生化指标及其脏器指数与对照组相比无显著性差异(p>0.05),3个剂量组间比较也无显著性差异(p>0.05).即中药CA安全无毒性.

The maximal tolerance dosage and long-term toxicity of mice were determined by maximal tolerance dosage test and feeding test which lasted 30 days. The results showed that the maximal tolerance dosage was 160 g/kg which was 160 times of clinical dosage per day; no significant difference existed between the control group and respective tested group (P<0.05) by determining the general states, body weight, hematology, blood biochemistry and the weight ratio of organ/body, and there was no significant difference (P>0.05) among the three dosage groups. The Chinese medicine CA is security and nontoxic.