2型糖尿病下肢血管病变与生化指标的相关性研究

ASSOCIATION BETWEEN INDICTIONS IN SERUM AND LOWER EXTREMITY ARTERIAL DISEASE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

目的 探讨血脂、血糖、一氧化氮等与 2型糖尿病下肢血管病变发生的关系。方法 2型糖尿病患者用葡萄糖氧化酶法测定血糖、胆固醇氧化酶法测定总胆固醇、甘油三酯磷酸氧化酶法测定甘油三酯、聚乙烯硫酸盐沉淀法测定低密度脂蛋白、用硝酸还原酶法检测一氧化氮水平变化 ,采用彩色多普勒超声判定 2型糖尿病患者下肢血管病变。结果 2型糖尿病伴有下肢血管病变 (LEDA)与年龄、家族史、近 1年血糖控制、LDL -C有相关性 ;与血清一氧化氮水平无明显相关性 (P <0 .0 5)。结论 在 2型糖尿病下肢血管病变的发生中年龄、家族史、血糖控制不良、血脂代谢紊乱起重要作用 ,患者血管一氧化氮合成、释放无明显减少。

Objective To study the possible association between blood sugar, blood fat, nitric oxide and lower extremity arterial disease in type 2 diabetic patients. Methods Fasting glucose, blood lipid were determined by a behring nephelometor using monoclonal antisera and enzyme end, the determination of serum nitric oxide level in type 2 diabetic patient was made by nitric acid reductase method. The arteries of bilaeral lower extremities were detected by colour Doppler fordetermining the pathology of low extremity arteries. Results Age, family history, fasting glucose controlled last year, fasting LDL-C, postprandial apoA-Ⅰrelated independently and significantly with LEAD, but there was no significant difference between serum nitric oxide level of type 2 diabetes with and without lower extremity arterial disease by multiple stepwise logistic regression analyses. Conclusion LEDA occurred easily in older patients with longer diabetic course. Fasting LDL-C, fasting blood sugar controlled last year and postprandial apoa-Ⅰ were impacting factors. There was not significant reductions in endothelial nitric oxide release of type 2 diabetes with lower extremity arterial disease.