上腹部手术患者血清高敏C-反应蛋白和肿瘤坏死因子α水平的变化

HIGH-SENSITIVITY C-REACTIVE PROTEIN AND TUMOUR NECROSIS FACTOR α CHANGES IN PATIENTS UNDERGOING UPPER ABDOMINAL SURGERY

目的 探讨上腹部手术患者术后血清高敏C -反应蛋白 (hs-CRP)和肿瘤坏死因子α(TNF -α)的变化及临床意义。方法 采用胶乳增强免疫透射比浊法和ELISA法对 2 0例上腹部手术患者术前、术中 1h、术后 2 4 ,72 ,1 2 0h分别进行hs -CRP和TNF -α含量测定。结果 术后 2 4hhs-CRP含量急剧升高 ,72h达到高峰 ,与各时间点比较 ,差异有统计学意义 (P <0 .0 1 ) ;1 2 0h后迅速下降回落。TNF -α与术前比较差异无统计学意义 (P >0 .0 5)。结论 监测术后hs-CRP含量变化有利于创伤预后判断。

Objective To investigate the changes and the significance of high-sensitivity C-reactive protein(hs-CRP) and tumour necrosis factor α(TNF-α) on patients undergoing upper abdominal surgery. Methods Hs-CRP and TNF-α concentrations were determined before induction of anesthesia, 1h after skin incision,24h,72h and 120h after surgery. Results Hs-CRP concentrations at 72h after surgery was significantly higher than those of 1h after skin incision,24h and 120h after surgery(P<0.01). No significant changes between pre- and post-operative serum TNF-αconcentrations was found(P>0.05). Conclusion Monitoring the levers of the hs-CRP after surgery may contribute to evaluating surgical trauma.