摘要
目的 研究CD4 4s (standardformofclusterofdifferentiation 4 4 )在脑胶质瘤中的表达 ,明确CD4 4s与胶质瘤分级和复发的关系 ,探讨其与脑恶性肿瘤侵袭浸润的相关性。方法 收集脑胶质瘤 4 3例 ,免疫组化法检测CD4 4s蛋白的表达 ,同时以RT PCR法检测CD4 4smRNA的表达。正常脑组织标本作阴性对照。结果 CD4 4s蛋白和CD4 4smRNA在胶质瘤中异常高表达 ,且与胶质瘤分级、术后复发密切相关 ,是胶质瘤术后复发的主要风险因子。结论 CD4 4s的表达与胶质瘤分级密切相关 ,其定量分析有助于胶质瘤术后复发判断的主要因素之一。
Purpose To observe the expression of CD44s in glioma and discuss the relation of CD44s and invasiveness of glioma. Methods The expression of CD44s protein and CD44s mRNA were detected by using immunohistochemical and reverse transcription polymerase chain reaction(RT-PCR) in 43 glioma.Normal brain tissue was studied as negative control. Results CD44s protein,as well as CD44s mRNA,was highly expressed in glioma and significantly higher than that in normal brain tissue (P<0.05).The CD44s expression in glioma was related to its pathologic grade and recurrence (P<0.05). Conclusions CD44s may play an important role in invasive process.CD44s expression may be a useful predictor for classification and recurrence in glioma.
出处
《复旦学报（医学版）》
CAS
CSCD
北大核心
2005年第2期212-215,F004,共5页
Fudan University Journal of Medical Sciences
