幽门螺杆菌感染与动脉粥样硬化性血栓性脑梗死及腔隙性脑梗死的关系

THE RELATIONSHIPS OF HELICOBACTER PYLORI AND ATHEROTHROMBOTIC INFARCTION AND LACUNAR INFARCTION

目的 观察幽门螺杆菌 (Hp)感染、血清白细胞介素 - 8(IL - 8)与动脉粥样硬化性血栓性脑梗死 (简称 :动脉粥样硬化性脑梗死 )及腔隙性脑梗死的关系。方法 采用病例对照的研究方法 ,选择初发动脉粥样硬化性脑梗死 1 50例 (A组 )、初发腔隙性脑梗死1 50例 (B组 )、健康体检者对照 1 50例 (C组 )。用酶联免疫吸附分析 (ELISA)法检测三组血清标本的Hp特异性抗体IgG(Hp -IgG) ,同时检测血清IL - 8浓度等。结果 A、B、C三组Hp -IgG阳性率分别为 :87% (1 31 / 1 50 )、68% (1 0 2 / 1 50 )、58% (87/ 1 50 ) ,A组与C组比较差异有统计学意义 (χ2 =32 .49,P <0 .0 1 ,OR =4.99,95 %CI :2 .79～ 8.92 ) ;B组与C组比较差异无统计学意义 (P >0 .0 5) ;A组与B组比较差异有统计学意义 (χ2 =1 6 .1 6 ,P <0 .0 1 ,OR =3 .2 4 ,95 %CI:1 .80～ 5 .86)。A组的IL - 8浓度与B组和C组比较差异有统计学意义 (P <0 .0 1 ) ,B组与C组的IL - 8浓度比较差异无统计学意义 (P >0 .0 5)。结论 Hp感染与动脉粥样硬化性脑梗死发病相关 ,与腔隙性脑梗死发病无相关性 ;动脉粥样硬化性脑梗死发病后血清IL - 8浓度升高。

Objective To study the relationships of helicobacter pylori(Hp) infection and atherothrombotic infarction and lacunar infarction. Methods Adopt the case-control study,to choose the 150 of the first atherothrombotic infarction (group A), the first lacunar infarction 150 (group B ) and the contrast 150 (group C). By enzyme-linfed immunosorbent assay (ELISA),peculiar antibody IgG of Hp (Hp-IgG ) and interleukin-8(IL-8) measured in the serum samples of three groups. Results The positive rate of Hp-IgG in group A,B and C is 87% (131/150),68%(102/150) and 58%(87/150).The positive rate of group A was significantly higher than group C (χ 2=32.49,P<0.01,OR=4.99,95% CI:2.79～ 8.92 ). The compare between group B and group C,the difference is not significant(P>0.05). The positive rate of group A was significantly higher than group B (χ 2=16.16,P<0.01,OR=3.24,95% CI:1.80～5.86).IL-8 density of group A is significantly higher than group B and group C (P<0.01).There is no difference between group B and group C (P> 0.05 ). Conclusion Helicobacter pylori infection correlates with atherothrombotic infarction,but not lacunar infarction. The serum IL-8 density rises after atherothrombotic infarction.