gp130信号可上调神经前体细胞表面分子CXCR4的表达

The gp130 signal increases the expression of CXCR4 on the neural progenitor cells

gp130信号参与了神经前体细胞(NPC)的自我更新,敲除gp130分子的胚胎不能正常地发育,可导致胎儿在出生前夭折。CXCR4是趋化因子基质细胞源因子(stromalcellderivedfactor-1α,SDF-1α)已知的唯一受体,表达CXCR4的NPC可在体外被SDF-1α趋化而定向迁移,在神经功能缺损的修复中起着重要的作用。gp130和CXCR4分子之间可能存在着一定的相关性。本实验在发现NPC表达gp130和CXCR4的基础上,采用gp130激发型单克隆抗体激发NPC,结果表明能上调NPC表达CXCR4分子以及增强NPC的迁徙能力,从而揭示了gp130信号在胚胎NPC定向迁移中可能起着重要的作用。

Glycoprotein 130 (gp130)signaling is thought to participate in the self-renewal of neural stem cell (NSC),when gp130 is knockout, embryo can't develop normally, and the fetus will die before birth. CXCR4 is the unique ligand of the chemokine stromal cell derived factor-1α(SDF-1α). The neural progenitor cells (NPC)express CXCR4, and they can move directionally through the chemotract by SDF-1α, this plays an important role in the restore of neurologic impairment. There may be a relationship between gp130 and CXCR4 these two molecules. Here, base on the finding that the NPC express gp130 and CXCR4 , we stimulated NPC using gp130 monoclonal antibody, the result showed that gp130 signal may increase the expression of CXCR4 on the NPC, even more, enhance the moving ability of NPC, so that open out the important role of gp130 can signal in the directional movement of NPC in embryo.