摘要
本文对25例急性心肌梗塞(AMI)患者血浆环磷酸腺苷(cAMP)、环磷酸鸟苷(cGMP)与心肌酶谱的动态变化相关性研究。同时设正常对照30例。结果:患者于入院时和入院后 8、6、24、48、72小时和 7天分别测试的 cAMP、CGMP含量均呈水平降低直到逐渐恢复。与正常对照比较 P<0.01。在同样时间测心肌酶谱:AST、CK、LDL、HBDH均明显升高与对照组比较有显著性差异。CAMP、cGMP与心肌酶谱均有相关性。但cAMP与心肌酶入院时和入院后8、16、48小时相关性最明显 P<0.05—0.01。cGMP与心肌酶入院后 8、16、48小时相关性最显著P<0.01—0.05。提示血浆核苷酸水平在AMI时可作为一项重要的检测指示,有助于预测心功能、心律失常、梗塞面积大小及预后等。
Flasma cAMP and cGMP contents were measured on admission and atlst, 8th,16th, 48th, 72nd hour and7th day after admission separately in 25 patients withAMI. The myocardial enzymes contents also measured at the same time. The resultswere as follows: (1) the cAMP and cGMP cointents were decreased horizontally butthe myocardial enzymes (ASK, CK, LDL, HBDH) contents were increased obviously in AMI; (2) there was significant difference comparing with that of control subjcts(n = 30) (p <0. 01); (3) there was a definite correlation between the plasmanucleotide and myocandial enzymes contents during AMI especially within 48 hoursafter admission (r = 0. 82) (P=0. 01). This study sugested that the plasma cAMP andcGMP contents may be a Valuable data to Predict cardiel function, arrhyrthmia,infarctive area and prognosis in AMI.