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P70 S6激酶在腮腺腺泡细胞癌中表达的研究 被引量：4

P70 S6 kinase expression in acinic cell carcinoma
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摘要 目的:研究P70S6激酶信号通路在腮腺腺泡细胞癌中的作用。方法:用免疫组化方法、Westen印迹分析测定腮腺腺泡细胞癌中P70S6激酶的表达。结果: 免疫组化的结果与Westen印迹分析一致,和正常组织相比,腮腺腺泡细胞癌中P70S6K的表达明显增加。结论:P70S6K的表达增加是提示腮腺腺泡细胞癌发生的重要生物化学指标。 Objective:To observe the expression of P70 S6 kinase(P70 S6K) in parotid acinic cell carcinoma. Methods:P70 S6K expression was examined by means of SP immunohistochemical technique and Western blot test in 30 cases of parotid acinic cell carcinoma. Results:Western blot revealed that P70 S6K expression in parotid acinic cell carcinoma was 58% higher than that in normal parotid tissue. Immunohistochemical assay showed that positive expression ratio of P70 S6K in parotid acinic cell carcinoma and in normal parotid tissue was 100.0% and 33.3%(P<0.01) respectively. Conclusion:High expression of P70 S6K may be an important biological factor of oral acinic cell carcinoma development.
作者 刘奕 兰仁刚 冯翠娟 张扬 于秉治
机构地区 中国医科大学口腔医学院 辽东学院医学部 中国医科大学基础医学院生化教研室
出处 《实用口腔医学杂志》 CAS CSCD 北大核心 2005年第2期171-173,共3页 Journal of Practical Stomatology
基金 973国家基础研究重点课题资助(No. 1999055900 2)
关键词 P70 S6激酶 腮腺腺泡细胞癌 P70 S6K Acinic cell carcinoma
分类号 R739.8 [医药卫生—肿瘤]
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共引文献23

同被引文献35

  • 1胡德渝.我国口腔健康、疾病趋势及发展方向[J].中国实用口腔科杂志,2009,2(9):513-516. 被引量：46
  • 2刘奕,杨鸣良,张扬,于秉治.哺乳动物的雷帕霉素靶蛋白及其底物在口腔鳞状细胞癌中的表达[J].华西口腔医学杂志,2004,22(4):331-333. 被引量：8
  • 3刘奕,张扬,杨明良,阎秀林,陈亚非,于秉治.mTOR/eIF-4EBP1信号通路在粘液表皮样癌发生中的作用[J].临床口腔医学杂志,2004,20(6):325-327. 被引量：7
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实用口腔医学杂志
2005年 第2期

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