消痔灵局部注射治疗血管瘤后VEGF的变化及意义

Serum VEGF level of the patients with hemangioma before and after Xiaozhiling injection

目的:寻找一种客观指标来反映血管瘤患者经消痔灵局部注射后的临床效果,探讨血管内皮生长因子(VEGF)与血管瘤发病机制的关系。方法: 用免疫酶标技术分别检测 10例正常人, 10例血管瘤患者治疗前、经消痔灵局部注射 1周后及 8例 1个月后外周血血清中VEGF的浓度。结果: 10例血管瘤患者血清中VEGF浓度明显高于正常人组(P<0. 01);经消痔灵局部注射 1周后血清中VEGF浓度与血管瘤患者组无明显区别(P>0. 01); 8例血管瘤患者经消痔灵局部注射 1月后外周血血清中VEGF浓度与正常人组无明显差别(P>0. 01).结论:VEGF可以作为一种客观依据来反映局部注射消痔灵法的临床治疗效果及预后;血管瘤患者局部注射治疗消痔灵方法临床效果确切。

Objective:To observe the effects of Xiaozhiling on the serum vascular endothelial growth factor(VEGF) level of the patients with hemangioma.Methods:10 healthy subjects (control group) and 10 hemangioma patients (treatment group) were included.The serum VEGF level were evaluated by ELISA in both groups.The treatment group was injected with Xiaozhiling once.VEGF level of the treatment group were measured before, one week after and one month(only 8 patients) after Xiaozhiling injection.Results:The serum VEGF concentrations (pg/ml) of the healty subjects, hemangioma patients without treatment, the patients 1 week after injection of Xiaozhiling and those 1 month after injection were 97.3±15.1,799.3±84.1,828.1±68.8 and 105.6±13.5 respectively. 1 week after injection tumor volume decreased by more than 25% in all the 10 patients.Conclusions:In situ injection of Xiaozhi ling may be a method for the treatment of hemangioma.