胰岛素治疗与胰岛B细胞休息的相关性研究

Relationship among insulin treatment and pancreatic Bcell rest.

目的探讨短期胰岛素强化治疗对2型糖尿病(T2DM)患者胰岛B细胞功能的影响.方法2003-11～2004-09在中国医科大学第一临床学院收治T2DM患者,应用化学免疫发光法测定强化治疗前后T2DM患者血清胰岛素和C肽水平.结果强化治疗后的T2DM患者OGTT试验中0、30、60、120、180min血清胰岛素和C肽水平均较治疗前明显升高.结论短期胰岛素强化治疗可使胰岛素分泌减低的T2DM患者胰岛B细胞得到休息,从而促其功能部分恢复.

Objective To study the effect of short-term inte ns ive insulin treatment on the pancreatic B-cell function in type 2 diabetic mell itus (T2DM).Methods Insulin and C-peptide serum levels were measured befor e and after intensive insulin treatment in T2DM by chemical luminescence immunoa ssay.Results The levels of insulin and C-peptide were increased at 0、30、60、120、180min in OGTT in T2DM after insulin intensive treatment.Conclusion Short-term intensive insulin treatment can partiall y improve the B-cell function of T2DM with lower function and made it rest.