摘要
目的探讨G蛋β3亚单位基因(GNB3)多态性与原性高血压的关系。方法高血压患者110例,健康对照者150例,采用聚合酶链反应(PCR)和限制性内切酶切割的方法分析GNB3多态性及分布,同时记录性别及血压。结果与健康组比较,EH组各基因型分布及等位基因频率无显著性差异,CC与T等位基因比较P=0.051;EH组中TT基因型患者收缩压水平显著高于CC/CT型(P=0.003)。结论G蛋白β3亚单位基因(GNB3)多态性参与高血压的发生,发展过程,且与收缩压密切相关。
Objective To study the relation between G proteinβ3 Subnit (GNB3) C825T dimorphism and blood pressure in Chinses essential hypertension (EH) patients. Methods One hundred and ten essential hypertension patients and matched controls one hundred and fifty were selected. Genotypes of the polymorphisms were determined by polymerase chain reaction(PCR)and PCR products were digested by restriction endonucleases. Blood pressure and distribution of body fat were also used. Results Genotype distribution in hypertension patients did not differ significantly from healthy controls. In contrast to CC genetype, frequency of the T allele mildy highter(P=0.051). systolic blood pressure between CC genetype and T allele was statistically signstically significant(P=0.003). Conclusion Our results demonstrate that the GNB3 825T allele is associated with EH, Especially with systolic blood pressure.
