经尿道电汽化术联合膀胱灌注和中药综合治疗浅表性膀胱肿瘤

Transurethral electrovaporization combined with intravesical chemotherapy and traditional chinese medicine therapy for treatment of superficial bladder tumor

目的总结应用经尿道膀胱肿瘤电汽化术(TUEVBt)联合膀胱灌注和中药治疗浅表性膀胱肿瘤的疗效。方法采用TUEVBt联合术后膀胱灌注THP、IL-2及给予华蟾素治疗浅表性膀胱肿瘤36例。男27例,女9例,平均55岁。肿瘤单发21例,多发15例,病理分级G-G,分期Ta-T,肿瘤直径0.3￣3.8cm。结果手术131均一次成功,平均手术27min,术中平均出血量<16mL,无膀胱穿孔或术后继发性出血等严重并发症,也无水中毒并发症。36例随访5￣17个月,平均9个月,复发2例,复发率5.6%。结论经尿道电汽化术联合膀胱灌注及应用华蟾素是治疗浅表性膀胱肿瘤的一种理想方法。

To evaluate medical effects of transurethral eleotrovaporation of bladder tumor(TUEVBt), combined with intravesical chemotherapy and traditional chinese medicine therapy on bladder tumor. 36 patients with superficial bladder tumors underwent TUEVBt with postoperative intravesical instillation of pirarubicin(THP) plus interleukin-2(IL-2) and iv drip of traditional chinese Medicine(cinobufacini) after operation. There were 27 male patients and 9 female patients with an average age of 55. The growth had been single in 21 and multiple 15. The diameter of the tumor was 0.3~3.8 cm with the pathology grade G1-G3 and Clinical stage Ta-T1. The procedure had been successful in all. The mean resection time was 27 minutes, the mean of bleeding was less than 16 ml and no intraoperatire bladder perforation or secondary hemorrhage and water intoxication occurred. All patients were followed up for 5 to 17 months (averagely 9 months). The recurrence rate in 36 patients of the group was 5.6%(2/36). [Conclusions] TUEVBt combined with intravesical chemotherapy and cinobufacini iv drip after operation is effective in the treatment of superficial bladder tumor with fewer adverse effects. The ragimen is not only reliable but also safe.