检测冠心病患者α_1-酸性糖蛋白和C-反应蛋白的意义

α_1-acid glycoprotein and C-reactive proteinin patients with coronary heart disease

目的 探讨不同类型冠心病(CHD)患者α1 酸性糖蛋白(AAG)和C 反应蛋白(CRP)的变化及其临床意义。方法 选择28例急性心肌梗死患者(AMI组),35 例不稳定型心绞痛患者(UAP组),30 例稳定型心绞痛患者(SAP组),30例非冠心病患者(对照组),分别测定其血浆 AAG 和 CRP 水平。所有患者均行冠状动脉造影,按Gensini积分法评定其冠状动脉狭窄程度,对结果进行统计学分析。结果 ①AMI组血浆 AAG、CRP水平高于 UAP组、SAP组和对照组(P<0.001); UAP组血浆 AAG、CRP 水平高于 SAP 组和对照组(P < 0.001); SAP 组血浆AAG、CRP水平稍高于对照组,但差异无统计学意义(P>0.05)。②随着冠状动脉狭窄程度加重,即 Gensini积分的增加,AAG、CRP水平升高越明显(P<0.001)。③冠状动脉3 支病变和双支病变组血浆 AAG、CRP水平高于单支病变组(P<0.005)。结论 血浆AAG和CRP水平可作为识别 CHD高危患者、监测病情变化的指标,其升高程度与冠状动脉粥样硬化程度有明显相关性。

Objective To observe the change and the clinical significance of plasma α 1-acid glycoprotein(AAG) and C-reactive protein(CRP) levels in different types of coronary heart disease(CHD). Methods AAG and CRP were measured in 28 cases of acute myocardial infarction(AMI), 35 unstable angina pectoris (UAP) , 30 stable angina pectoris(SAP) and 30 controls. Coronary angiography was performed in all the patients,and the severity of coronary stenosis was evaluated by the Gensini score. Results ①AAG and CRP levels were higher in AMI group than those in UAP group, SAP group and controls(P< 0.001); The levels of AAG and CRP in UAP group were higher than those in SAP group and controls(P< 0.001); There is no difference between the latter two groups(P> 0.05).② AAG and CRP levels were significantly correlated with severity of coronary stenosis(Gensini Score)(P< 0.001). ③AAG and CRP levels in three branches' and double branches' groups were higher than those of single branch group(P< 0.005).Conclusion AAG and CRP levels might be used to identify high-risk patients with CHD and to monitor the change of the disease , and they are related with severity of coronary atherosclerosis.