摘要
目的:通过对急性脑梗塞患者血清抗血管内皮细胞抗体(Antiendothelialcellantibodies,AECA)和血浆可溶 性血栓调节蛋白(solublethrombomdulin,sTM)的联合检测,旨在探讨急性脑梗塞临床发病与血管内皮细胞损伤的 内在关系。方法:采用间接荧光免疫法和双抗体夹心ELISA法检测66例急性脑梗塞患者(急性脑梗塞组)和35例 献血员标本(对照组)的AECA、sTM水平。结果:急性脑梗塞组的AECA阳性率显著高于对照组(P<0.01);急性 脑梗塞组治疗前sTM水平显著高于对照组(P<0.01);急性脑梗塞组治疗3~4周后sTM水平与对照组相比无显 著性差异(P>0.05)。结论:AECA、TM的检测可作为急性脑梗塞血管内皮损伤的观察指标,有助于脑血管病变的 诊断和治疗。
Objective:To examine serum antiendothelial cell antibodies (AECA) and plasma soluble thrombomdulin (sTM) in patients with acute cerebral infarction and interrelationship in the onset of acute cerebral infarction and endothelial cellular damage. Methods: AECA and TM were detected in 66 patients with acute cerebral infarction and in the controls with IIF and ELISA. Results: In 66 cases of acute cerebral infarction, the positive rate of AECA was 37.9% (25/66), and was much higher than that in the controls (P<0.01). In first 2 weeks of the disease, the sTM level was much higher than that of the normal group (P<0.01). After 4 weeks, the sTM level in treated patients was no difference from that in the normal group (P>0.05). Conclusion: The results suggest that the determinations of AECA and TM in patients with acute cerebral infarction have a certain value for the diagnosis and Treatments.
出处
《实用临床医学(江西)》
CAS
2005年第3期12-14,共3页
Practical Clinical Medicine
关键词
脑梗塞
急性
抗血管内皮细胞抗体
血栓调节蛋白
cerebral infarction,acute
antiendothelial cell antibodies
soluble thrombomdulin