多态信息量(PIC)等于杂合度吗?

Does the Polymorphism Information Content Equal the Heterozygosity?

多态信息量用于连锁分析时对标志基因(或标志序列)的多态性估计,杂合度则用于群体遗传学上对群体多态性的描述;前者主要服务于基因定位和产前诊断,而后者则可对进化因子的效应予以分析,两者不仅含义不同,而且往往值也不同.本文对上述问题进行了分析并提出了自已的一些看法.

The polymorphism information content(PIC)that measures the extent of polymorphism for marker gene(s)or marker sequence(s)is applied to the linkage analysis of pedigree(s),whereas the heterozygosity that estimates polymorphic amount within a population or a subpopulation is used to population genetics study,so that PIC is different from heterozygosity.This paper will discuss points at length some of which are personal views.