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硫酸氨基葡萄糖:第1个经临床证明的骨关节炎疾病改善药物 被引量：8

Glucosamine sulfate: the first clinical proven disease modifying drug for osteoarthritis
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摘要 综述了近年发表的关于硫酸氨基葡萄糖临床研究的3项回顾性分析以及最为瞩目的关于硫酸氨基葡萄糖的临床研究报告,给出了骨关节炎疾病改善药物(DMOAD)发展的过去、现状和期望的一个侧面,一个最有希望的侧面,希望有助于推动DMOAD在中国的应用、评价与发展。 The publish summarized three latest systemic reviews and given details of the landmark trail on glucosamine sulfate introduce the yesterday, today and a good future of disease modifying drug for osteoarthritis(DMOAD) on a view. It will helpful to promote the clinical, the assessment and the developing of DMOAD in China.
作者 Marliese ANNEFELD
机构地区 罗达药厂
出处 《中国新药与临床杂志》 CAS CSCD 北大核心 2005年第4期253-262,共10页 Chinese Journal of New Drugs and Clinical Remedies
关键词 骨关节炎 关节疾病 药物疗法 关节间 隙狭窄 硫酸氨基葡萄糖 osteoarthritis joint disease drug therapy joint space narrowing glucosamine sulfate
分类号 R684.3 [医药卫生—骨科学] R977.4 [医药卫生—药品]
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参考文献26

  • 1SETNIKAR I, ROVATI LC. Absorption, distribution, metabolism and excretion of glucosamine sulfate [ J ]. Arzneimittelforschung,2001,51(9) : 699-725.
  • 2NOYSZEWSKI EA, WROBLEWSKI K, DODGE GR, et al. Preferential incorporation of glucosamine into the galactosamine moieties of chondroitin sulfates in articular cartilage explants [ J ]. Arthritis Rheum, 2001,44(5) :1089-1095.
  • 3BASSLEER C, ROVATI L, FRANCHIMONT P. Stimulation of proteoglycan production by glucosamine sulfate in chondrocytes isolated from human osteoarthritic articular cartilage in vitro[ J]. Osteoarthritis Cartilage, 1998, 6(6) :427-434.
  • 4PIPERNO M, REBOUL P, HELLIO Le GRAVERAND MP, et al.Glucosamine sulfate modulates dysregulated activities of human osteoarthritic chondrocytes in vitro [ J ]. Osteoarthritis Cartilage,2000.8(3) :207-212.
  • 5DODGE GR, JIMENEZ SA. Glucosamine sulfate modulates the levels of aggrecan and matrix metalloproteinese-3 synthesized by cultured human esteoarthritis articular chondrocytes [ J ]. Osteoarthritis Cartilage, 2003, 11(6) : 424-432.
  • 6YARON I, SHIRAZI I, JUDOVICH R, et al. Glueosamine sulfate inhibits nitric oxide and stromelysin production in cartilage cultures and reverses IL-1 inhibition of osteoarthritic articular cartilage synthesis[J]. Ann Rheum Dis,2001,60 Suppl:50.
  • 7LARGO R, ALVAREZ-SORIA MA, DIEZ-ORTEGO I, et al.Glucosamine inhibits IL-1β-induced NFkappaB activation in human osteoarthritic chondrocytes [J]. Osteoarthritis Cartilage, 2003, 11(4) : 290-298.
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中国新药与临床杂志
2005年 第4期

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