激光血管成形术对内皮素基因表达的影响

Effect of Laser Angioplasty on Endothelin Gene Expression

内皮素是迄今已知的最强缩血管活性肽，并具很强的促有丝分裂作用。本实验对模型兔粥样硬化髂动脉行Ｎｄ：ＹＡＧ激光血管成形术，术后一个月，发现成形术后血管内皮素基因表达明显高于动脉粥样硬化血管和正常血管，提示内皮素在激光血管成形术后再狭窄中起一定的作用。

Endothelin is the most potent vasoconstrictor known by now. and it has powerful role in mitogenesis. The present study was performed with Nd: YAG Laser angioplasty in the atherosclerosis rabbit iliac artery one month after angioplasty,We discovered that endothelin gene expression was higher in angioplasty artery than atherosclerosis artery and normal artery. It suggests that endothelin play a role in restenosis.