2－芳酰氨基－5－［1－苯基－2－羟基－2－（对甲氧基苯）乙基］－1，3，4－噻二唑的合成

Synthesis of 2-Afoylamino-5-(1-phenyl-2-hydroxyanisethyl)-1,3,4-thiadiazoles

２－芳酰氨基－５－苄基－１，３，４－噻二唑１上５－位苄基在ＥｔＯＮａ／ＥｔＯＨ中生成负离子，再与对甲氧基苯甲醛亲核加成合成了一系列新的２－芳酰氨基－５－［１－苯基－２－羟基－２－（对甲氧基苯）乙基］－１．３，４－噻二唑２．化合物２的结构经元素分析，ＩＲ，￣ＨＮＭＲ和ＭＳ分析确证。初步观察了２抗菌活性。

Thirteen title compounds(2) were obtained by nucleophilic addition of benzyl car-banion of 2-aroylamino-5-benzyl-1,3,4-thiadiazoles(1) with anisaldehyde in EtONa/EtOHsolution. The structures of the compounds 2 were confirmed by elemental analysis, IR,￣1HNMR,and MS. The compounds were found to have some fungicidal activity.