IgA与非IgA系膜增生性肾炎患者外周血淋巴细胞亚群表达研究

Study on Different Expression of Peripheral Lymphocyte Subgroup in Patients with IgA and Non IgA Mesangial Proliferative Glomerulonephritis Nephropathy

目的 研究原发性IgA系膜增生性肾炎(IgAMsPGN)及非IgA系膜增生性肾炎(nonIgAMsPGN)的周围血淋巴细胞亚群的表达异常。方法 随机选取47例IgAMsPGN患者,40例nonIgAMsPGN患者以及5 5 %正常健康体检人员作为对照。结果 与对照组相比,两组病人B细胞、CD4 细胞、CD4 /CD8比率均有升高(P <0.0 5 ) ,而NK细胞有所下降(P <0.0 1)。而且IgAMsPGN组患者的NK细胞明显比nonIgAMsPGN组的NK细胞水平低(P <0 .0 5 )。结论 IgAMsPGN和nonIgAMsPGN病人均有周围血淋巴细胞亚群的异常,这说明这两种肾小球的发病与可能免疫异常相关,而IgAMsPGN组病人NK细胞显著低于nonIgAMsPGN 。

Objective To study the different expression of peripheral lymphocyte subgroup in the primary IgA mesangial proliferative glomerulonephritis nephropathy (IgA MsPGN) and non IgA mesangial proliferative glomerulonephritis nephropathy (non IgA MsPGN). Methods 47 IgA MsPGN patients, 40 non IgA MsPGN patients and 55 healthy controls were chosen randomly. The T cell, B cell, CD4, CD8,, CD4/CD8 and NK cell were detected with coulter flow cytometer. Results The amount of B cell, CD4 cell and the ratio of CD4/CD8 were higher (P<0.05), however, the amount of NK cell was lower (P<0.01) in two case groups compared with those in control group. Moreover, NK cell in IgA MsPGN patients was significantly lower than that in non IgA MsPGN patients (P<0.05). Conclusions The peripheral lymphocyte subgroup disorder exists in both IgA MsPGN and non IgA MsPGN patients, which suggests that immune disorder may contribute to the happen of these two nephritis. The discrepancy of NK cell in the two case groups suggests that NK cell may be involved in the different mechanism of IgA MsPGN and non IgA MsPGN.