维生素A营养状况对青年免疫功能的影响及补充效果观察

EFFECTS OF VITAMIN A STATUS AND VITAMIN A SUPPLEMENTATION ON IMMUNE FUNCTION IN YOUTH

本文筛选血红蛋白、血清白蛋白及维生素Ｅ在正常范围的健康青年７１名，测定血清维生素Ａ含量及６项免疫学指标。结果显示，血清维生素Ａ平均含量为１．３６±０．４３μｍｏｌ／Ｌ。与各项免疫指标的相关分析，维生素Ａ与外周血Ｔ淋巴细胞百分数和淋巴细胞转化率间呈显著正相关（ｒ＝０．２３６６，Ｐ＜０．０５，ｒ＝０．３０８６，Ｐ＜０．０１），与其它免疫指标未见显著相关性。维生素Ａ含量较低人群的外周血Ｔ淋巴细胞百分数及淋巴细胞转化率明显低于维生素Ａ含量正常人群（Ｐ＜０．０５），于补充维生素Ａ后显著升高（Ｐ＜０．０１）。血清ＩｇＧ、ＩｇＡ、ＩｇＭ含量在两组人群间及补充前后无显著性差别。研究结果表明，维生素Ａ对维持和增强人体细胞免疫功能具有一定作用，对体液免疫功能未见显著影响。

he relationship between serum vitamin A(VA)level and VA supple-mentation on immune function Was studied in young healthy adults.The results demonstrated that the average serum VA concentration was1.36±0.43μmol/L,and there was significant possitive correlation between serumVA level and blood T lymphocytes rate or T lymphocyte transformation rate(r=0.2366 P<0.05,r=0.3086 P<0.01), but no correlation betWeen serum VAlevel and serum IgG, IgA, IgM and C3 levels was observed. Seventeen subjects who had low serum VA levels(<1.12μmol/L)weresupplied with totally VA 320,200 IU(3.35mmol) in 4 weeks, serum VAlevels, blood Tnlymphocyte rates and lymphocyte transformation rateswere significantly enhanced (P<0.001, P<0.01).But there were no significantdifferences in IgG, IgA and IgM levels before and after supplementation. In brief the results showed that VA could enhance cell-mediated immune function, but not humoral-mediated immune function.