锌对免疫器官的影响

FFFECTS OF ZINC ON IMMUNE ORGANS IN RATS

通过建立大鼠缺锌（ＺＤ）、高锌（ＺＥ）模型，研究锌对免疫器官——骨髓、胸腺、脾脏的影响。结果表明：（１）ＺＤ、ＺＥ组体重、体重增长值、饲料效价均非常显著地低于配对（ＰＦ）组和自由喂养（ＡＬ）组，缺锌补锌（ＺＤ＋ＡＬ）组达正常水平。（２）ＺＤ组血清、毛发、股骨、肝脏锌均非常显著地低于ＰＦ、ＡＬ组，而ＺＥ组则相反，ＺＤ＋ＡＬ组达正常水平。（３）ＺＤ、ＺＥ组的胸腺重量、胸腺指数、胸腺肽量和胸腺活性均非常显著地低于ＰＦ、ＡＬ组，ＺＤ＋ＡＬ组达正常水平。（４）ＺＤ、ＺＥ组脾脏重量、脾脏指数均非常显著地低于ＰＦ、ＡＬ组，ＺＤ＋ＡＬ组达正常水平。（５）ＺＤ、ＺＥ组骨髓细胞３Ｈ一ＴｄＲ掺入率和外周血白细胞总数显著下降，其中尤以淋巴细胞减少为着。（６）骨髓细胞、脾脏淋巴细胞周期显示ＺＤ、ＺＥ组静止期细胞明显增高，而增殖期细胞下降，与ＰＦ、ＡＬ组间差别非常显著。以上结果提示，适量锌有促进免疫器官——骨髓、胸腺、脾脏发育和功能活动的作用。而缺锌和高锌则抑制免疫器官的发育和免疫细胞的功能。

he effects of Zinc on bone marrow,thymus and spleen of rats fedzinc一deficient(ZD)and zinc一excessive(ZE) diets were observed.Thefindings were as follows:1.The body weight, weight gain and feed efficiency value of ZD andzBrats were significantly lower than those of pair-fed group(PF) or adlibitum group(AL).The parameters were restored to the normal level afterzinc repletion for the ZD animals(ZD + AL). 2.The zinc content in serum, hair and liver was significantly lower inZD rats than those in PE 、AL and ZD + AL, but was significantly higher inZE animals. 3. The weight of thymus,thymus index,thymic peptide content andthymin activity were all significantly lower in ZD and ZE rats than in PF,AL andZD+AL. 4.The weight of the spleen and the spleen index were significantly1ower in ZD and ZE,atts than those in PF.AL and ZD+AL.5.The3H -TdR incorporation rate of bone marrow, the leucocyte countof peripheral blood and especially the proportion of lymphocytes in leuco-cvtes were significantly lower in ZD and ZE rats than those in PF, AL andZD+AL. 6.The G0/G1 phase of cell cycle of bone marrow and splenic lymphocyteswas significantly higher and S,G2 + M phase lower in ZD and ZE rats thanin PF,AL and ZD+AL. It was concluded that adequate dietary zinc was important for the de一velopment and normal function of immune organs but either deficient or ex-cessive amount of zinc could suppress their functions.