摘要
人群试验发现维生素Ａ可改善血红蛋白水平和铁营养状况，为明确作用机理进行了动物试验。以雄性断乳的ＮＩＨ小鼠６０只分为三组，用不同的方式给予基础饲料及含维生素Ａ的配合饲料。喂饲８０天后，一次性胃肠给予￣（５９）ＦｅＣｌ＿３（以８．１４×１０￣５Ｂｑ／１００ｇｂｗ），并计数整体、连续六天的粪便及脏器的放射性。结果表明：血浆维生素Ａ与￣（５９）Ｆｅ排泄率，肝、脾的￣（５９）Ｆｅ放射性及肝内总铁含量呈负相关，维生素Ａ缺乏动物骨髓￣（５９）Ｆｅ放射性显著低于正常组。可见维生素Ａ可能改善铁吸收和铁由贮存组织向所需器官的转运，促进造血功能等。这些作用可能与维生素Ａ促进上皮生长及其对转铁蛋白合成有关。
t was found that vitmin A could raise the
hemoglobin level and im-prove anemia stdatus.In order to reveal the mechanism,animal
experimentwas held.After dividing 60 malc,weaned,NIH mice into three groups,they were fed
with basic diet and synthetic diet containing vitamin A indifferent ways After intragastic
administration of 8.14 × 10￣5￣(59)Fe/100g bodyweight at the day on 80 days feeding,the
radioactivity of whole-body,daily stools for periods of 6 days and organs were measured.It was
de-monstrated that there were negative correlations between plasma levcls ofvitamin A and rate
of Fe excreted,radioactivity of livcr and spleen andtotal iron content in liver.The radioactivity of
marrow in vitamin A de-ficient animals was significantly lower than that of controls(Ⅰand Ⅱ)。
Vitamin A may increase the absorption of iron and accelerate iron mobi-lization from storage
tissues into liemocytopoietic organ──bone marrow,where iron is needed. These functions
may be concerned with the effectof vitamin A on the epithelium growth of intestine and synthesis
of trans-ferrin.
出处
《营养学报》
CAS
CSCD
北大核心
1994年第2期138-143,共6页
Acta Nutrimenta Sinica
基金
浙江省教育委员会
关键词
维生素A
贫血
铁代谢
vitamin A anemia iron metabolism Department of Nutrition,the
People’s Hospital of Zhejiang Province,Hangzhou 310014
