N-烷基-O-烷基-O-(1-氰基-2,2,2-三氯乙基)硫代磷酰胺酯的合成

Synthesis of N-alkyl-O-alkyl-O-(1-Cyan-2,2,2-trichloroethyl) phos-phoramidothioates

八十年代初,文献报道了O,O—二烷基—O—(氰基氯烷基)硫代磷酸酯具有良好的生物活性。我们在深入研究了氰基多卤烷基硫代磷酸酯及相应的磷酰胺的基础上,采用在相转移催化剂三乙基苄基溴化铵作用下,O—烷基硫代磷酰二氯直接与三氯乙醛、氰化钠水溶液反应,制备三个未见文献报道的O—烷基—O—(l—氰基—2,2,2—三氯乙基)硫代磷酸一氯2a～2c,然后用胺化的路线合成了八个未见文献报道的目标化合物3a～3h:

Eight new N-alkyl-O-alkyl-O-(1-cyan-2,2,2-trichloroethyl) phosphoramidothioates with the general formuk Cl3CeH(CN)OP(SXOR1) (NR2R3) were synthesized, The title com- pounds have been characterized by IR, NMR and MS. Some of them have good activities against nematodes (Meloidogyne Spp.).