化学修饰的寡核苷酸:合成、性质和应用

Chemically Modified Oligonucleotides: Synthesis, Properties and Potential Applications

本文综述了近年来化学修饰的寡核苷酸研究的进展,介绍了化学修饰的寡核苷酸的种类,化学合成方法,生物作用原理及应用方面已达到的成就及前景。

This review deals with the progress in the research of chemically modified oligonucleotides: the synthesis, the chemical and biological properties and the potential applications as a new research tool and new therapeutic approach.