西贝素β-氮氧化物及其二维核磁共振谱

Imperialine β-N-Oxide and its 2D NMR Spertra

1976年苏联学者从 Petlium eduarde中分出西贝素氮氧化物（imperialine N—oxide）,但与以西贝素（imPerialine）为原料经 H2O2氧化制得的合成品并不一致,且文中未见两种西贝素氮氧化物的结构。自后,日本学者从淅贝母（Fritillaria tjimbesgii）中分出淅贝乙素氮氧化物（VerticinoneN—Oxide）1和浙贝母碱氮氧化物（Verticine N-oxide）2。而1与2中N→O键的β—取向仅仅基于:

Imperialine β-N-oxide 3 isolated from the bulbs of Fritillaria siechuanica S. C. Che was identified on the basis of the chemical and spectral methods. Its all 1H and 13C-signals have been assigned unambigously based on studies of 2D NMR. In addition, assigments of the chemical shifts of some 13C-signals of 3 reported in literature 4 were revised.