87例慢性苯中毒临床分析

目的了解苯中毒的个体易感性和传统治疗方法对中毒患者的影响。方法对87例苯中毒患者临床资料作分析。结果同样接触水平的人群中只有部分发病,而病情严重程度不一,78例(89.7%)治疗后完全康复,8例(9.2%)明显缓解,1例死亡。各组病人疗程不一,部分中、轻度中毒病人疗程比重度中毒疗程长,传统治疗对部分苯致再生障碍性贫血病例疗效不佳。结论提示可能存在对苯的个体易感性差异,部分苯致再生障碍性贫血传统治疗欠佳,检测与个体易感性相关的生物标志物对于筛选那些不宜接触苯的工人将有很大的价值。

Objective Subject To learn the influence of traditional treatment and individual susceptibility for the Chronic Benzene Poisoning(CBP). Methods The clinical data of 87 CBP cases were analyzed. Results Only a part of the population with the same level of benzene exposure would suffer from the disease, CBP cases with the same benzene exposure level exhibited different extents of severity of the illness. 78(89.7%) of the cases recovered completely, 8(9.2%) cases improved obviously, one(1.1%) died. Period of treatment in some mild or moderate CBP cases were longer than the severe cases. Some benzene-induced aplastic anemia cases showed no response to the traditional treatment. Conclusion This evidence suggests strongly the existence of individual susceptibility. Detection of the biological markers regarding the individual susceptibility would be valuable for the screening of workers who are not suitable to be exposed to benzene.