纳络酮治疗重度新生儿缺氧缺血性脑病的疗效观察

Clinical Observation of Treating Neonatal Hypoxic Ischemic Encephalopathy with Naloxone

目的观察纳络酮治疗重度新生儿缺氧缺血性脑病(HIE)的疗效。方法在常规治疗的基础上对36例重度HIE加用纳络酮治疗,并与常规治疗的24例比较。结果治疗组有效率明显优于对照组(p<0.01)。纳络酮可使患儿临床症状明显好转,明显缩短中枢性呼吸衰竭、循环不良和胃肠功能紊乱消失时间,并提高其存活率。结论纳络酮治疗HIE疗效显著,未见副作用发生。

Objective To observe the effect of naloxone on HIE. Methods On the routine therapy ,the healing group with thirty-six cases of HIE received therapy on naloxone , and compared with the contrast group on routine therapy. Results The effective rate of the healing group was higher than that of the contrast group (p<0.01). Naloxoane can significantly shorten the time of respiratory failure, circulatory system dysfunction and gastro-intestine function failure , and increase the survival rate . Conclusion The therapy with naloxone on HIE is remarkable ,and it has no side effect.