惊厥性疾病患儿血浆和脑脊液生长抑素的变化

Changes of Somatostatin Levels in Plasma and Cerbrospinal Fluid of Children with Convulsive Diseases

目的探讨血浆、脑脊液生长抑素(SOM)在惊厥发生中的作用及其临床意义。方法选取惊厥性疾病患儿67例,分别在入院d1、d7采取静脉血,d1采脑脊液(CSF)标本,采用放射免疫分析法检测血浆和CSF中SOM水平。结果1.惊厥组d1、7血浆SOM水平分别为(39.23±11.00)、(29.47±9.40)ng/L,d7较d1显著下降(t=21.530P<0.001);惊厥各组d7与d1自身比较有显著差异(t=16.551,10.968,13.715P均<0.01);脑炎无惊厥组d7(20.57±4.82)ng/L较d1(21.66±5.01)ng/L下降,但无显著差异(t=1.321P>0.05);对照组d1(19.58±6.04)ng/L,惊厥组与脑炎无惊厥组、对照组相比均有显著差异(t=6.847,7.921P均<0.01),惊厥组各组之间也有显著差异(F=56.114P<0.01);2.惊厥组CSF中SOM为(44.14±12.50)ng/L,脑炎无惊厥组为(22.88±5.60)ng/L,对照组为(18.88±5.27)ng/L。惊厥组较脑炎无惊厥组、对照组均显著升高(t=7.406,7.786P均<0.001),惊厥各组之间也有显著差异(F=51.150P<0.01)。3.惊厥发作次数多则血浆和CSF中SOM水平高,经直线相关与回归分析,d1、7血浆SOM水平与d1CSF中SOM水平显著正相关(r=0.956,0.830P均<0.001)。结论惊厥性疾病患儿血浆、CSF中SOM水平均显著增高,但SOM水平在惊厥发生的不同阶段变化不同。血浆SOM水平能间接反映CSF水平,且与惊厥发?

Objective To study the changes of somatostatin(SOM) in plasma and cerebrospinal fluid (CSF) of children with convulsive diseases.Methods Sixty-seven children with convulsive diseases were studied as following:obtaining the samples of plasma in the 1st and 7th day after being in hospital,and the samples of CSF in the 1st after being in hospital.We investigated the changes of SOM in plasma and CSF with radioimmunoassay(RIA).Results 1.Convulsive group:the concentration of SOM in plasma in the 7th day(29.47±9.40 ng/L) was significant lower than that in the 1st day(39.23±11.00 ng/L)(t=21.530 P<0.001).Each group in convulsive subjects were significant different(t=16.551,10.968,13.715 P<0.01).Encephalitis group without convulsion:The concentration of SOM in plasma in the 7th day(20.57±4.82 ng/L) was lower than that in the 1st day(21.66±5.01 ng/L),but there was no significant difference(t=1.321 P>0.05).The concentration of SOM in plasma in the 1st day in control group was(19.58±6.04) ng/L.There were significant differences in convulsive group and encephalitis group without convulsion, control group(t= 6.847,7.921 P<0.01).There was also positive difference in each group in convulsive subject(F=56.114 P<0.01),2.The concentrations of SOM in CSF in the 1st day was(44.14±12.50) ng/L(convulsive group),(22.88±5.60) ng/L(encephalitis group without convulsion),(18.88±5.27) ng/L(control group),respectively.There were positive differences in convulsive group and encephalitis group without convulsion,control group(t=7.406,7.786 P<0.001).Each group in convulsive subjects showed positive difference(F=51.150 P<0.01)3.The levels of SOM in plasma and CSF had correlated to the degree of convulsion.The concentrations of SOM in plasma in the 1st and 7th day had significantly positive correlation to those in CSF in the 1st day (r=0.956 P< 0.001).Conclusions There are levels of SOM in plasma and CSF in cases with convulsions,changing in the different course of convulsion.The levels of SOM in plasma can indirectly reflect the levels of SOM in CSF,positively correlating with seizure severity.These findings suggest that monitoring SOM in children with convulsive diseases can help to guild diagnosis and treatment of convulsive diseases.$$$$