原发性肝癌选择性肝动脉插管化疗栓塞术患者疼痛干预的效果观察

The pain relief of primary hepatic carcinoma patients with transcatheter aterial chemoembolization

目的探讨原发性肝癌选择性肝动脉插管化疗栓塞术有效减轻疼痛的方法。方法选择158例原发性肝癌患者,将其随机分为干预组和常规组各79例。常规组在导管置入肝固有动脉时直接注入化疗药物及栓塞剂,干预组先注入2%利多卡因100mg+地塞米松10mg,再注入化疗药物和栓塞剂。结果干预组患者使用止痛药为14例,占17.7%;杜冷丁用量为(14.3±5.8)mg;常规组使用止痛药49例,占62.0%,杜冷丁用量为(85.3±2.3)mg;经t检验,t=26.59,P<0.05,具有显著性差异。结论选择性肝动脉插管化疗栓塞术中推注化疗药及栓塞剂前注入利多卡因和地塞米松,可有效地避免和减轻术中及术后的疼痛,保证手术的顺利进行,减轻术后止痛药的用量。

Objective To investigate the method to relieve pains in primary hepat ic carcinoma (PHC) patients with transcatheter aterial chemoembolization (TACE). Methods 158 PHC patients were randomized evenly into the experimental group an d control group. In the experimental group, 2% Lidocaine 100 mg and Dexamethason e 10 mg were injected into hepatic arteries before TACE. In the control group, T ACE was conducted in the routine way. Results Dolantine was used in 14 cases an d 49 cases, accounting for 17.7% and 62.0% in the experimental group and the con trol group, respectively. The dosages were (14.3±5.8)mg and (85.3±2.3)mg, resp ectively, with significant difference between the groups (t=26.59, P<0.05). Con clusion During TACE, injection of Lidocaine and Dexamethasone may effectively r elieve postoperative pains, so it ensures the smooth performance of TACE and thu s reduces the use of dolantine after operation.