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两亲性嵌段共聚物胶束的研究进展 被引量：17

Progress of Amphiphilic Block Copolymer Micelles
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摘要 综述了两亲性嵌段共聚物胶束的形成机理、组成、结构、理化性质、制备方法、影响因素、药学方面的应用等进展。 Theassembling mechanism,composition,structure, physiochemicalproperties, preparation method and influence factors, as well as the applications in pharmaceutics of the amphiphilic block copolymer micelles are reviewed.
作者 施斌 方超 裴元英
机构地区 复旦大学药学院药剂教研室
出处 《中国医药工业杂志》 CAS CSCD 北大核心 2005年第4期239-243,共5页 Chinese Journal of Pharmaceuticals
关键词 胶束 嵌段共聚物 药物载体 综述 micelle block copolymer drug carrier review
分类号 R944.9 [医药卫生—药剂学]
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参考文献29

  • 1赵剑曦,邱羽.Pluronic嵌段共聚物胶束作为靶向药物载体[J].精细化工,2001,18(2):72-75. 被引量：12
  • 2Lavasanifar A, Samuel J, Kwon GS. Poly (ethylene oxide) -block-poly (1-amino acid) micelles for drug delivery [J]. Adv Drug Deliv Rev, 2002, 54 (2): 169-190.
  • 3Alexandridis P, Alan Hatton T. Poly (ethylene oxide) -poly (propylene oxide) -poly (ethylene oxide) block copolymer surfactants in aqueous solutions and at interfaces:thermodynamics, structure, dynamics, and modeling [J].Collids Surf A, 1995, 96 (1/2): 1-46.
  • 4Zhang L, Hu Y, Jiang X, et al. Camptothecin derivative-loaded poly (caprolactone-co-lactide) -b-PEG-b-poly (caprolactoneco-lactide) nanoparticles and their biodistribution in mice[J].J Controlled Release, 2004, 96 (1): 135-148.
  • 5Kim SC, Kim DW, Shim YH, et al. In vivo evalution of polymeric micellar paclitaxel formulation:toxicity and efficacy [J]. J Controlled Release, 2001, 72 (1-3): 191-202.
  • 6Alexandridis P, Yang L. SANS investigation of polyether block copolymer micelle structure in mixed solvents of water and formamide, ethanol, or glycerol [J]. Macromolecules, 2000,33 (15): 5574-5587.
  • 7Kataoka K, Harada A, Nagasaki Y. Block copolymer micelles for drug delivery: design, characterization and biological significance [J]. Adv Drug Deliv Rev, 2001, 47 (1): 113-131.
  • 8Alexandridis P, Holzwarth JF, Alan Hatton T. Micellization of poly (ethylene oxide)-poly (propylene oxide) -poly (ethylene oxide) triblock copolymers in aqueous solutions: thermodynamics of copolymer association [J]. Macromolecules, 1994,27 (9): 2414-2425.
  • 9Chung JE, Yokoyama M, Aoyagi T, et al. Effect of molecular architecture of hydrophobically modified poly (N-isopropylacrylamide) on the formation of thermoresponsive core-shell micellar's drug carriers [J]. J Controlled Release, 1998, 53(1-3): 119-130.
  • 10Jeong B, Bae YH, Lee DS, et al. Biodegradable copolymers as injectable drug-delivery systems [J]. Nature, 1997, 388 (6645):860-862.

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中国医药工业杂志
2005年 第4期

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