摘要
[目的]探讨三七总皂苷(PanaxNotoginsenySaponins,PNS)对大鼠急性心肌缺血(acutemyocardialischemia,AMI)模型血流动力学的影响。[方法]Wistar大鼠建立急性心肌缺血模型,随机分为假手术组、模型组、PNS小剂量组、PNS大剂量组。治疗7d后,分别测定左室血流动力学指标,包括左室收缩压(LVSP),左室舒张末期压(LVEDP),左室内压最大上升及下降速率(±dp/dtmax)。[结果]PNS可以降低LVEDP,升高±dp/dtmax。[结论]PNS治疗AMI可以改善心脏功能,大剂量应用对左室收缩和舒张功能均有显著提高作用。
Objective To explore the effect of Panax Notoginseny SaponinsPNS on the hemodynamics in rats with acute myocardial ischemia (AMI). Methods AMI was established in rats by ligature of coronary artery. They were randomly divided into sham-operated group,model group,small-dose group of PNS and large-dose group of PNS. After treatment for 7 days,the hemodynamic indexes of left ventricle (LVSP,LVEDP,±dp/dt max)were measured. Results PNS could reduce the LVEDP and increase the ±dp/dt max. Conclusion PNS can improve the cardiac function,and large-doses of PNS have marked improveing effect on systolic and diastolic function of left ventricle.
出处
《天津中医药》
CAS
2005年第2期158-160,共3页
Tianjin Journal of Traditional Chinese Medicine
基金
国家重点基础研究发展规划"973"资助项目(1999054403)
关键词
三七总皂苷
急性心肌缺血
血流动力学
Panax Notoginseny Saponins
acute myocardial ischemia(AMI)
hemodynamics