三七总皂苷对心肌缺血大鼠血流动力学影响实验研究

Experimental Study on Effects of Panax Notoginseny Saponins on Hemodynamics in Rats with Myocardial Ischemia

[目的]探讨三七总皂苷(PanaxNotoginsenySaponins,PNS)对大鼠急性心肌缺血(acutemyocardialischemia,AMI)模型血流动力学的影响。[方法]Wistar大鼠建立急性心肌缺血模型,随机分为假手术组、模型组、PNS小剂量组、PNS大剂量组。治疗7d后,分别测定左室血流动力学指标,包括左室收缩压(LVSP),左室舒张末期压(LVEDP),左室内压最大上升及下降速率(±dp/dtmax)。[结果]PNS可以降低LVEDP,升高±dp/dtmax。[结论]PNS治疗AMI可以改善心脏功能,大剂量应用对左室收缩和舒张功能均有显著提高作用。

Objective To explore the effect of Panax Notoginseny SaponinsPNS on the hemodynamics in rats with acute myocardial ischemia (AMI). Methods AMI was established in rats by ligature of coronary artery. They were randomly divided into sham-operated group,model group,small-dose group of PNS and large-dose group of PNS. After treatment for 7 days,the hemodynamic indexes of left ventricle (LVSP,LVEDP,±dp/dt max)were measured. Results PNS could reduce the LVEDP and increase the ±dp/dt max. Conclusion PNS can improve the cardiac function,and large-doses of PNS have marked improveing effect on systolic and diastolic function of left ventricle.