27例原发性高血压病人血清B_2^-微球蛋白测定的临床意义

THE CLINICAL SIGNIFICANCE OF ESTIMATION OF SERUM β_2—MICROGLOBULIN IN 27 CASES OF PRIMARY HYPERTENTION

采用放射免疫法测定27例原发性高血压病人和29例健康人的血清β_2-m含量。原发性高血压组血清β_2-m值明显高于对照组(p<0.01)。此项检查远比BUN、Cr的检测敏感,阳性率分别为62.9％、40.7％和26.9％。因此,用血清β_2-m估价原发性高血压病人早期肾小球滤过率减退是一项敏感、简便、可靠的方法,可作为高血压病分期一项参考指标,对指导临床用药,保护肾功能和预后判断、疗效观察均有实用价值。

Serum content of β_2-microglobulin (β_2-m) was detected with the method of radioimmunoassay in 27 cases of primary hypertention and 29 healthy subjects. The serum β_2-m level in primary hypertention group was significantly higher than that in the healthy group (P<0.001). The determination of serum concentration of β_2-m has a much higher sensitivity than that of BUN and creantine and their positive rates were 62.9%, 40.7% and 26.9% respectively. It is emphasized that the method is superior to other methods, simple and expedient for evaluating the impairment of glomerular filtration at the early stage of primary hypertention.